Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Diuretics in pediatrics : current knowledge and future prospects.

Maria M J van der Vorst1, Joana E Kist, Albert J van der Heijden

  • 1Department of Paediatrics, Faculty of Medicine, University of Kuwait, Kuwait City, Kuwait. Maria@hsc.edu.kw

Paediatric Drugs
|August 11, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Near-Infrared Fluorescence Imaging for Intraoperative Ureter Identification: A Systematic Review.

The Journal of surgical research·2026
Same author

Interpretation of Chemistry, Hematology and Coagulation Laboratory Results in Early-Phase Clinical Pharmacology Trials; a Retrospective Analysis Based on the Placebo Arm of Randomized-Controlled Trials.

Clinical and translational science·2026
Same author

Early immune responses to intradermal lipopolysaccharide in healthy volunteers: prednisolone's impact on TLR4-mediated inflammation.

Frontiers in immunology·2026
Same author

Clinical Validation of Imaging Biomarkers in Mycosis Fungoides.

Experimental dermatology·2026
Same author

Standardizing clinical trials in near-infrared fluorescence imaging: a workflow and regulatory framework proposal.

Npj imaging·2026
Same author

Pharmacokinetics, safety, tolerability and fluorescence imaging of nizaracianine triflutate administered in three divided doses to healthy volunteers.

British journal of clinical pharmacology·2026

Pediatric diuretics are essential for managing fluid overload but optimal dosing is unknown. Further pharmacokinetic and pharmacodynamic studies in children are needed for safe and effective diuretic therapy.

Area of Science:

  • Pediatric Pharmacology
  • Renal Physiology
  • Drug Metabolism

Background:

  • Diuretics are commonly prescribed in pediatric patients for fluid overload.
  • Indications include congestive heart failure and renal failure.
  • Current dosing regimens are often empirical and lack pediatric-specific data.

Purpose of the Study:

  • To review current knowledge on diuretics in children.
  • To highlight gaps in understanding pediatric pharmacokinetics and pharmacodynamics.
  • To emphasize the need for evidence-based dosing strategies.

Main Methods:

  • Literature review of pharmacology, pharmacokinetics, pharmacodynamics, and clinical use of pediatric diuretics.
  • Analysis of factors influencing diuretic action in children, including renal maturation and function.

Related Experiment Videos

Main Results:

  • Diuretic pharmacokinetics vary significantly across pediatric age groups and disease states.
  • Renal function critically impacts diuretic delivery to the tubular lumen.
  • Existing dosing recommendations are primarily extrapolated from adult studies.

Conclusions:

  • Optimal diuretic dosing in children remains largely undetermined.
  • Pediatric-specific pharmacokinetic and pharmacodynamic studies are crucial.
  • Development of evidence-based dosing models is necessary for all administration routes.