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Allergic rhinitis and sinusitis in asthma: differential effects on symptoms and pulmonary function
Anne E Dixon1, David A Kaminsky, Janet T Holbrook
1Pulmonary and Critical Care Medicine, University of Vermont, Burlington, 05401, USA. anne.dixon@vtmednet.org
Chest
|August 11, 2006
Summary
Allergic rhinitis and sinusitis are linked to worse asthma symptoms and more exacerbations, particularly in poorly controlled asthma, but do not impact lung function.
Area of Science:
- Pulmonology
- Allergy and Immunology
- Clinical Research
Background:
- Allergic rhinitis and sinusitis frequently co-occur with asthma.
- Understanding this association is crucial for managing asthma effectively.
Purpose of the Study:
- To investigate the impact of self-reported allergic rhinitis and sinusitis on lower airway disease in a large asthma cohort.
- To identify specific associations between these conditions and asthma severity markers.
Main Methods:
- A cohort study involving 2,031 participants from the SIIVA trial and 488 from the LODO trial.
- Baseline assessment of allergic rhinitis and sinusitis, followed by measurements of lung function and asthma control.
- Monitoring of asthma exacerbations throughout the study duration.
Main Results:
- Over 70% of participants reported allergic rhinitis or sinusitis.
- Sinusitis and allergic rhinitis were associated with increased asthma symptoms and sleep disturbances.
- While allergic rhinitis did not affect exacerbation rates, sinusitis was linked to more exacerbations in the LODO trial.
Conclusions:
- Allergic rhinitis and sinusitis are associated with increased asthma symptom severity.
- These conditions correlate with more frequent asthma exacerbations in poorly controlled asthma.
- No significant association was found between allergic rhinitis, sinusitis, and reduced lung function.
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