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Viscosity, hemostasis and inflammation in atherosclerotic heart diseases

Gábor Késmárky1, Gergely Fehér, Katalin Koltai

  • 1First Department of Medicine, University of Pécs, Pécs, Hungary. gabor.kesmarky@aok.pte.hu

Clinical Hemorheology and Microcirculation
|August 11, 2006
PubMed

Insights

This study reveals that hemorheological and hemostaseological factors significantly impact atherosclerotic heart diseases. Effective antiplatelet treatment correlates with better outcomes, highlighting their importance in vascular health.

Area of Science:

  • Cardiovascular Medicine
  • Hematology
  • Vascular Biology

Background:

  • Atherosclerotic diseases impair vascular reserve and reduce pressure gradients, accelerating tissue ischemia due to decreased blood fluidity.
  • Previous research indicated worsened plasma and whole blood viscosities in patients with acute coronary syndromes, chronic coronary artery disease, and post-angioplasty.

Purpose of the Study:

  • To investigate the interplay of hemorheological and hemostaseological factors in cardiovascular and cerebrovascular diseases, including diabetes mellitus.
  • To assess the relationship between risk factors, medication, and hemorheological/hemostaseological parameters.

Main Methods:

  • Evaluated hemorheological variables (viscosities, hematocrit, red blood cell aggregation).
  • Assessed hemostaseological parameters (plasma fibrinogen, von Willebrand factor (vWf)).
  • Measured platelet aggregation, risk factors (lipids, smoking, glucose), and medication.

Main Results:

  • A significant portion of vascular patients exhibited poor ex vivo platelet inhibition.
  • Effective antiplatelet therapy correlated with lower plasma fibrinogen, reduced red blood cell aggregation, and fewer recurrent vascular events.
  • Diabetic patients showed elevated vWf activity linked to hemoglobin A1c, not fasting glucose.

Conclusions:

  • Hemorheological and hemostaseological factors play an active, interactive role in atherosclerotic heart diseases.
  • Effective antiplatelet treatment, influenced by these factors, is associated with improved clinical outcomes.
Abstract

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