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Related Experiment Videos

Hemorheological parameters and aging.

Gergely Feher1, Katalin Koltai, Gabor Kesmarky

  • 1First Department of Medicine Division of Cardiology, University of Pecs, School of Medicine, Pecs, Hungary.

Clinical Hemorheology and Microcirculation
|August 11, 2006
PubMed
Summary
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Hemorheological parameters show minimal clinical correlation with advancing age, suggesting disease, not aging, drives changes in older adults. This impacts understanding cardiovascular and cerebrovascular event risks.

Area of Science:

  • Cardiovascular Science
  • Gerontology
  • Hematology

Background:

  • Impaired hemorheological parameters are linked to increased cardiovascular and cerebrovascular event risk.
  • Aging is a significant factor in cardiovascular health, necessitating investigation into age-related hemorheological changes.

Purpose of the Study:

  • To investigate the relationship between hemorheological parameters and advancing age in patients with cardio- and cerebrovascular conditions.
  • To determine if age-related hemorheological changes have clinical significance or are primarily associated with co-occurring diseases.

Main Methods:

  • Analysis of hemorheological data (hematocrit, fibrinogen, red blood cell aggregation, plasma and whole blood viscosity) from 6236 cardio- and cerebrovascular patients.
  • Stratification of patients into age groups (young, middle-aged, old) and a selected subgroup with matched parameters to control for confounding factors.

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  • Blood samples collected after overnight fasting for precise parameter determination.

    • Main Results:

    • A statistically significant but low correlation was observed between hemorheological parameters and age in the overall population.
    • In specific age groups, particularly older males, hematocrit, red blood cell aggregation, and whole blood viscosity showed negative correlations with age.
    • In a selected population controlling for risk factors, hemorheological parameters did not correlate with advancing age.

    Conclusions:

    • The correlation between hemorheological parameters and age in the general population lacks clinical significance due to large sample size.
    • Hemorheological parameters appear largely independent of aging itself; elevated levels are more indicative of underlying diseases rather than advanced age.
    • Findings suggest focusing on disease management rather than age alone when assessing hemorheological risks in patients.