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Ocular surface sealants and adhesives.

Subir Singh Bhatia1

  • 1Department of Ophthalmology, University of Florida, Gainesville, Florida 32610, USA. Subirb@yahoo.com

The Ocular Surface
|August 11, 2006
PubMed
Summary

Ophthalmic tissue adhesives, including cyanoacrylates and fibrin glues, offer improved outcomes for corneal perforations and tissue attachment. New agents show promise for ocular surface protection and sealing.

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Area of Science:

  • Ophthalmology
  • Biomaterials Science
  • Surgical Innovation

Background:

  • Tissue adhesives have a long history in ophthalmic applications.
  • Cyanoacrylate glues are traditionally used, particularly for corneal perforations, with proven long-term benefits.
  • Fibrin-based glues are increasingly used as suture substitutes and for surface sealing.

Purpose of the Study:

  • To review the current landscape and future potential of tissue adhesives in ophthalmology.
  • To highlight the efficacy of established adhesives and emerging agents.
  • To underscore the role of adhesives in advancing ophthalmic care.

Main Methods:

  • Literature review of synthetic and biologic tissue adhesives in ophthalmology.
  • Analysis of clinical applications and outcomes for various adhesive types.
  • Evaluation of emerging adhesive technologies and their potential uses.

Main Results:

  • Cyanoacrylate glues demonstrate significant long-term success in treating corneal perforations.
  • Fibrin glues are effective for biologic tissue attachment and as surface sealants.
  • Polyethylene glycols and other novel agents show promise as ocular surface protectants and sealants.

Conclusions:

  • Tissue adhesives are integral to modern ophthalmic practice, offering alternatives to traditional methods.
  • Continued research and development in tissue adhesives promise more effective and efficient ophthalmic treatments.
  • Expanded use of fibrin glue and exploration of new agents like polyethylene glycols are recommended.

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