Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Sleep and fatigue in multiple sclerosis.

B R Stanton1, F Barnes, E Silber

  • 1Institute of Psychiatry, King's College London, London, SE5 8AF, UK.

Multiple Sclerosis (Houndmills, Basingstoke, England)
|August 12, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

EAN guideline on palliative care of people with severe, progressive multiple sclerosis.

European journal of neurology·2020
Same author

Beyond a physical symptom: the importance of psychosocial factors in multiple sclerosis pain.

European journal of neurology·2015
Same author

Distress improves after mindfulness training for progressive MS: A pilot randomised trial.

Multiple sclerosis (Houndmills, Basingstoke, England)·2015
Same author

A 500-kiloton airburst over Chelyabinsk and an enhanced hazard from small impactors.

Nature·2013
Same author

Cognitive behaviour therapy for common mental disorders in people with Multiple Sclerosis: A bench marking study.

Behaviour research and therapy·2013
Same author

Differential corticospinal tract degeneration in homozygous 'D90A' SOD-1 ALS and sporadic ALS.

Journal of neurology, neurosurgery, and psychiatry·2011
Same journal

Association of epiretinal membranes with disability in people with multiple sclerosis.

Multiple sclerosis (Houndmills, Basingstoke, England)·2026
Same journal

Epiretinal membranes in multiple sclerosis: A window into glial pathobiology?

Multiple sclerosis (Houndmills, Basingstoke, England)·2026
Same journal

Profiling the long-term risk of severe adverse events in a cohort of multiple sclerosis patients treated with different treatment sequences: Results from the Italian Multiple Sclerosis and Related Disorders Registry (I-MS&RD) (ProSA study).

Multiple sclerosis (Houndmills, Basingstoke, England)·2026
Same journal

UK consensus on pregnancy in multiple sclerosis: An update to 'Association of British Neurologists' guidance.

Multiple sclerosis (Houndmills, Basingstoke, England)·2026
Same journal

Comparative effectiveness of rituximab versus ocrelizumab in relapsing multiple sclerosis on clinical relapses and radiological outcomes in British Columbia, Canada.

Multiple sclerosis (Houndmills, Basingstoke, England)·2026
Same journal

Invisible symptoms in multiple sclerosis and their impact on social role participation: A multidimensional analysis.

Multiple sclerosis (Houndmills, Basingstoke, England)·2026
See all related articles

Sleep disturbances are common in multiple sclerosis (MS) and significantly linked to daytime fatigue. Addressing sleep issues like insomnia and nocturia may help manage MS-related fatigue and disability.

Area of Science:

  • Neurology
  • Sleep Medicine
  • Clinical Research

Background:

  • Fatigue is a primary disabling symptom in multiple sclerosis (MS).
  • The underlying causes of MS-related fatigue remain incompletely understood.
  • Sleep disturbances are frequently reported but their specific patterns and impact on fatigue are not well-characterized.

Purpose of the Study:

  • To determine the prevalence and patterns of sleep disturbances in MS outpatients.
  • To investigate the association between various sleep problems and fatigue severity.
  • To explore potential contributing factors to sleep disturbances in MS.

Main Methods:

  • A cohort of 60 outpatients with MS participated.
  • Participants completed the Fatigue Severity Scale (FSS) and Epworth Sleepiness Scale.

Related Experiment Videos

  • A 7-day sleep diary was used to record sleep patterns and disturbances.

    • Main Results:

    • High rates of fatigue (64%) and excessive daytime sleepiness (32%) were observed.
    • Frequent sleep disturbances included initial (42%), middle (53%), and terminal insomnia (58%).
    • Middle insomnia showed a significant correlation with daytime fatigue, even after adjusting for disability.

    Conclusions:

    • Sleep disturbance is prevalent in MS patients and linked to significant fatigue.
    • Common causes of insomnia include anxiety, pain, and nocturia.
    • Targeting sleep disturbances and associated symptoms may be a crucial strategy for managing MS fatigue.