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Related Experiment Video

Updated: Apr 16, 2026

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Distress improves after mindfulness training for progressive MS: A pilot randomised trial.

A Bogosian1, P Chadwick2, S Windgassen2

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Multiple Sclerosis (Houndmills, Basingstoke, England)
|March 14, 2015
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A mindfulness intervention delivered via Skype effectively reduced distress, pain, and fatigue in people with progressive multiple sclerosis (MS). This accessible, remote program proved potentially cost-effective for managing MS symptoms.

Keywords:
Multiple sclerosisanxietydepressiondistressmindfulnesspilot randomised control trialprogressive

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Area of Science:

  • Psychiatry and Behavioral Science
  • Neurology
  • Health Services Research

Background:

  • Mindfulness-based interventions (MBIs) are effective for managing anxiety, depression, and pain in chronic physical illnesses.
  • Progressive multiple sclerosis (MS) significantly impacts patients' quality of life, often involving distress, pain, and fatigue.

Purpose of the Study:

  • To assess the effectiveness and cost-effectiveness of a remote, Skype-delivered mindfulness intervention for individuals with primary and secondary progressive MS.
  • To reduce psychological distress in patients with progressive MS through a specially adapted, distant-delivered mindfulness program.

Main Methods:

  • Forty participants with progressive MS were randomized into an 8-week mindfulness intervention group (n=19) or a wait-list control group (n=21).
  • Standardized questionnaires measured mood, MS impact, symptom severity, quality of life, and service costs at baseline, post-intervention, and 3-month follow-up.

Main Results:

  • The mindfulness intervention group showed significantly lower distress scores post-intervention and at follow-up (p < 0.05) with large effect sizes (-0.67 to -0.97).
  • Significant reductions in pain, fatigue, anxiety, depression, and MS impact were observed in the intervention group compared to controls (effect sizes -0.27 to -1.12).
  • While no differences in quality-adjusted life years were found, the intervention demonstrated an 87.4% probability of saving service costs while improving outcomes.

Conclusions:

  • A Skype-delivered mindfulness intervention is accessible, feasible, and potentially effective for individuals with progressive MS.
  • This remote mindfulness program offers a promising, cost-effective approach to reducing distress and improving symptom management in progressive MS.