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Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis
Published on: March 9, 2018
An aspergilloma in an echinococcal cyst cavity
1Siyami Ersek Thoracic and Cardiovascular Surgery Center, Thoracic Surgery, Istanbul, Turkey. dr.caydemir@gmail.com
Abstract:
Aspergilloma is a saprophytic infection which can colonize preexisting lung cavities. The most common underlying diseases are tuberculosis, sarcoidosis, cavitary lung cancer, etc. Although aspergilloma can also occur in operated hydatid cyst cavities, only a few cases have been reported in literature. A 32-year-old female patient underwent cystectomy for the diagnosis of perforated intraparenchymal giant hydatid cyst located in the right upper lobe, reaching down to the hilum. Capitonnage was not performed and it was observed that a residual cavity remained in the cystectomy area. The patient was discharged; however, during clinical and radiological follow-ups, it was found that the residual cyst cavity had expanded. As it was thought that one of the drainage bronchi in the cyst cavity could have opened, the patient was reoperated. During the operation, it was noted that purulent fluid and necrotic tissues were present in the cystic cavity. It was seen that the posterior upper lobe segment was consolidated and not ventilated. Contents of the cavity were removed and the posterior upper lobe segment was resected. Histopathological examination revealed that the tissue in the cavity was that of an aspergilloma, and that chronic organized pneumonia and diffuse interstitial fibrosis were present in the resected segment. Refraining from surgical obliteration (capitonnage) of cyst cavities in cases of giant hydatid cysts extending to the hilum can lead to opportunistic infections such as aspergilloma.
Insights
Aspergilloma, a fungal infection, can develop in lung cavities after hydatid cyst surgery if the cavity is not fully closed. This case highlights the risk of opportunistic infections like aspergilloma in residual cavities.
Area of Science:
- Pulmonology
- Infectious Diseases
- Surgical Pathology
Background:
- Aspergilloma typically colonizes preexisting lung cavities from diseases like tuberculosis or lung cancer.
- It can rarely occur in cavities from operated hydatid cysts.
Observation:
- A patient developed an aspergilloma in a residual cavity after surgery for a giant hydatid cyst.
- The residual cavity expanded, leading to reoperation where purulent fluid and necrotic tissue were found.
Findings:
- Histopathology confirmed aspergilloma within the cavity.
- The resected lung segment showed chronic organized pneumonia and interstitial fibrosis.
Implications:
- Failure to surgically obliterate (capitonnage) large hydatid cyst cavities extending to the hilum increases the risk of opportunistic infections.
- This case underscores the importance of complete cavity management after hydatid cyst surgery to prevent complications like aspergilloma.
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