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The Comparative Toxicogenomics Database (CTD): a resource for comparative toxicological studies.

C J Mattingly1, M C Rosenstein, G T Colby

  • 1Mount Desert Island Biological Laboratory, Department of Bioinformatics, Salisbury Cove, Maine 04672, USA. cmattin@mdibl.org

Journal of Experimental Zoology. Part A, Comparative Experimental Biology
|August 12, 2006
PubMed
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The Comparative Toxicogenomics Database (CTD) links environmental chemicals to gene interactions, aiding human health research. It enables cross-species studies to understand chemical impacts and genetic susceptibility.

Area of Science:

  • Environmental health sciences
  • Genomics
  • Toxicology

Background:

  • Chronic diseases arise from complex interactions between environmental factors and genes.
  • Understanding these interactions is crucial for public health.
  • Environmental chemicals can significantly impact human health through biological pathways.

Purpose of the Study:

  • To develop and promote the use of the Comparative Toxicogenomics Database (CTD).
  • To identify and understand interactions between environmental chemicals and genes.
  • To facilitate cross-species comparative studies for toxicogenomics research.

Main Methods:

  • Developing a publicly available database (CTD).
  • Identifying chemical-gene interactions.

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  • Utilizing cross-species comparative sequence studies and diverse animal models.

    • Main Results:

    • CTD provides a resource for exploring chemical-gene interactions.
    • The database supports comparative toxicogenomics research.
    • Facilitates understanding of molecular mechanisms of environmental chemical action.

    Conclusions:

    • The Comparative Toxicogenomics Database (CTD) is a valuable resource for environmental health research.
    • Cross-species comparative approaches are essential for understanding toxicological mechanisms.
    • CTD aids in elucidating the genetic basis of differential susceptibility to environmental chemicals.