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Related Experiment Videos

The c-Myc target gene network.

Chi V Dang1, Kathryn A O'Donnell, Karen I Zeller

  • 1Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. cvdang@jhmi.edu

Seminars in Cancer Biology
|August 15, 2006
PubMed
Summary
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The oncogenic protein c-Myc broadly influences gene expression, regulating about 15% of genes involved in cell cycle, metabolism, and protein synthesis. Further research is needed to identify specific target genes distinguishing c-Myc

Area of Science:

  • Molecular Biology
  • Oncology
  • Genomics

Background:

  • The oncogenic protein c-Myc is known to influence gene expression.
  • Recent high-throughput studies have provided substantial evidence for c-Myc's role in regulating the transcriptome.

Purpose of the Study:

  • To summarize the current understanding of the c-Myc target gene network.
  • To highlight the functional implications of c-Myc in cellular processes and disease.

Main Methods:

  • Microarray gene expression profiling
  • Serial Analysis of Gene Expression (SAGE)
  • Chromatin immunoprecipitation (ChIP) followed by genomic array analysis
  • Myc-methylase chimeric proteins

Main Results:

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  • The c-Myc target gene network comprises approximately 15% of all genes across species.
  • c-Myc globally regulates transcription, with over-represented genes in cell cycle regulation, metabolism, ribosome biogenesis, protein synthesis, and mitochondrial function.
  • c-Myc represses genes involved in cell growth arrest and cell adhesion.
  • Overexpression of c-Myc can lead to apoptosis under specific conditions.

Conclusions:

  • c-Myc is a global transcriptional regulator with significant impact on cellular processes.
  • While many c-Myc targets are identified, those distinguishing physiological from tumorigenic functions require further delineation.