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DNA sequence recognition by bleomycin
1Department of Physiology & Pharmacology, University of Southampton, UK.
Anti-Cancer Drug Design
|February 1, 1990
Abstract:
The ability of bleomycin to cleave DNA fragments containing (TA)n and (GA)n/(CT)n inserts has been investigated. Bleomycin cuts efficiently after AT and GA though not at TA, AG and CT or TC. In the presence of ligands which modify DNA structure new cleavage products appear. It seems that the ability of bleomycin to discriminate between various sequences arises from their structural characteristics rather than merely from base-specific hydrogen bond contacts.