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A Model for Epilepsy of Infectious Etiology using Theiler's Murine Encephalomyelitis Virus
Published on: June 23, 2022
Multiple reversible MR signal changes caused by Epstein-Barr virus encephalitis.
G Hagemann1, H-J Mentzel, H Weisser
1Department of Neurology, Friedrich-Schiller-University, Erlanger Allee 101, 07740 Jena, Germany. hagemann@med.uni-jena.de
AJNR. American Journal of Neuroradiology
|August 16, 2006
Summary
Epstein-Barr virus (EBV) encephalitis can cause reversible brain lesions, particularly in the splenium of the corpus callosum. This case highlights EBV as a crucial consideration in diagnosing such reversible splenial lesions.
Area of Science:
- Neurology
- Infectious Diseases
- Radiology
Background:
- Epstein-Barr virus (EBV) is a common human herpesvirus.
- Encephalitis is inflammation of the brain, often caused by infections.
- Splenial lesions in the corpus callosum can have various etiologies.
Observation:
- A young male presented with acute febrile illness, neurological deficits including ataxia, seizures, and cognitive impairment.
- Magnetic Resonance (MR) imaging demonstrated characteristic reversible signal abnormalities.
Findings:
- MR imaging revealed reversible T2 and diffusion-weighted imaging signal intensities in the splenium of the corpus callosum and posterior hemispheres.
- A decreased apparent diffusion coefficient (ADC) was noted in the affected splenium, indicating restricted diffusion.
Implications:
- This case underscores the importance of considering EBV encephalitis in the differential diagnosis of reversible splenial lesions.
- Neuroimaging findings in EBV encephalitis can mimic other conditions, necessitating a comprehensive diagnostic approach.
- Early recognition and diagnosis of EBV encephalitis are crucial for appropriate management and potential prevention of long-term neurological sequelae.
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