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Related Experiment Videos

Multiple reversible MR signal changes caused by Epstein-Barr virus encephalitis.

G Hagemann1, H-J Mentzel, H Weisser

  • 1Department of Neurology, Friedrich-Schiller-University, Erlanger Allee 101, 07740 Jena, Germany. hagemann@med.uni-jena.de

AJNR. American Journal of Neuroradiology
|August 16, 2006
PubMed
Summary

Epstein-Barr virus (EBV) encephalitis can cause reversible brain lesions, particularly in the splenium of the corpus callosum. This case highlights EBV as a crucial consideration in diagnosing such reversible splenial lesions.

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Area of Science:

  • Neurology
  • Infectious Diseases
  • Radiology

Background:

  • Epstein-Barr virus (EBV) is a common human herpesvirus.
  • Encephalitis is inflammation of the brain, often caused by infections.
  • Splenial lesions in the corpus callosum can have various etiologies.

Observation:

  • A young male presented with acute febrile illness, neurological deficits including ataxia, seizures, and cognitive impairment.
  • Magnetic Resonance (MR) imaging demonstrated characteristic reversible signal abnormalities.

Findings:

  • MR imaging revealed reversible T2 and diffusion-weighted imaging signal intensities in the splenium of the corpus callosum and posterior hemispheres.
  • A decreased apparent diffusion coefficient (ADC) was noted in the affected splenium, indicating restricted diffusion.

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Implications:

  • This case underscores the importance of considering EBV encephalitis in the differential diagnosis of reversible splenial lesions.
  • Neuroimaging findings in EBV encephalitis can mimic other conditions, necessitating a comprehensive diagnostic approach.
  • Early recognition and diagnosis of EBV encephalitis are crucial for appropriate management and potential prevention of long-term neurological sequelae.