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Related Concept Videos

Genomic DNA in Eukaryotes00:58

Genomic DNA in Eukaryotes

Eukaryotes have large genomes compared to prokaryotes. To fit their genomes into a cell, eukaryotic DNA is packaged extraordinarily tightly inside the nucleus. To achieve this, DNA is tightly wound around proteins called histones, which are packaged into nucleosomes that are joined by linker DNA and coil into chromatin fibers. Additional fibrous proteins further compact the chromatin, which is recognizable as chromosomes during certain phases of cell division.
Organization of Genes02:07

Organization of Genes

Overview
RNA Splicing01:32

RNA Splicing

Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
Alternative RNA Splicing02:18

Alternative RNA Splicing

Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
Multi-species Conserved Sequences02:51

Multi-species Conserved Sequences

Next-generation sequencing technologies have created large genomic databases of a variety of animals and plants. Ever since the human genome project was completed, scientists studied the genome of primates, mammals, and other phylogenetically distant living beings. Such large-scale  studies have provided new insights into the evolutionary relationship between organisms.
Although the genome of each species varies greatly from each other, a few sequences are highly conserved. Such conserved DNA...
Alternative RNA Splicing02:18

Alternative RNA Splicing

Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...

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Related Experiment Video

Updated: Jul 16, 2026

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
09:34

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease

Published on: April 4, 2018

[EDAS, databases of alternatively spliced human genes].

R N Nurtdinov, A D Neverov, D B Mal'ko

    Biofizika
    |August 17, 2006
    PubMed
    Summary

    The EDAS database catalogs alternatively spliced human genes, detailing exon and intron information for mRNA and protein alignments. Users can filter data by significance level, aiding genetic research.

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    Last Updated: Jul 16, 2026

    Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
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    Published on: April 4, 2018

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    Identification of Alternative Splicing and Polyadenylation in RNA-seq Data
    08:35

    Identification of Alternative Splicing and Polyadenylation in RNA-seq Data

    Published on: June 24, 2021

    Area of Science:

    • Genomics
    • Bioinformatics
    • Molecular Biology

    Context:

    • Alternative splicing is a key mechanism for generating protein diversity in eukaryotes.
    • Understanding alternative splicing is crucial for deciphering gene function and disease mechanisms.

    Purpose:

    • To present the EDAS database, a comprehensive resource for alternatively spliced human genes.
    • To provide detailed information on gene structures, including exons, introns, and alternative splicing events.

    Summary:

    • EDAS (a database of alternatively spliced human genes) integrates data on protein, mRNA, and EST alignments.
    • It meticulously records all observed exons and introns and their elementary alternative forms.
    • The database allows users to filter results based on adjustable significance thresholds.

    Impact:

    • Facilitates research into gene structure and alternative splicing.
    • Supports the identification of novel splice variants and their functional implications.
    • Provides a valuable, accessible resource for the scientific community studying human genetics.