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Updated: Aug 6, 2026

A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
Intraepidermal animal-type melanoma
S Punjabi1, C Wright, F Teixeira
1Department of Dermatology, Hammersmith Hospitals NHS Trust, London, UK. sangeeta@ppunjabi.com
Abstract:
Animal-type melanoma is a rare variant of melanoma in humans.1 Its name is derived from its histological appearance, which is similar to that described in melanomas occurring in white or gray horses.2 All tumors are dermally located, and characterized by a proliferation of deeply pigmented elongated or rounded cells, showing moderate atypia and a low mitotic rate. In some tumors, secondary infiltration of the epidermis has been noted. More than half of the patients are younger than 30 years, and prognosis seems to be much better than that expected for a superficial spreading or nodular melanoma of the same size. We report the first case of animal-type melanoma in situ.
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