Related Experiment Videos
Synthesis and purification of two SP (6-11) analogues with enhanced selectivity for the NK-1 receptor
I Haro1, J L Torres, G Valencia
1Laboratory of Peptides, Biological Organic Chemistry Department, C.I.D., C.S.I.C., Barcelona, Spain.
International Journal of Peptide and Protein Research
|February 1, 1990
Abstract:
Two hexapeptide analogues of Substance P (6-11) have been synthesized. Replacement of Gly9 by proline provides a peptide with tenfold enhanced selectivity for the NK-1 receptor. The corresponding proline-containing glycopeptide incorporating a beta-D-glucopyranosyl residue linked to the side-chain of Glu6 was 100 times more selective than Substance P for the same receptor.