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Arterial wave reflections are associated with left ventricular diastolic dysfunction in Adamantiades-Behçet's disease

Ignatios Ikonomidis1, Kostas Aznaouridis, Athanasios Protogerou

  • 1Department of Clinical Therapeutics, University of Athens, Alexandra Hospital, Athens, Greece.

Journal of Cardiac Failure
|August 17, 2006
PubMed

Insights

Arterial stiffness, measured by aortic distensibility and augmentation index, is linked to left ventricular diastolic dysfunction in Adamantiades-Behçet's disease patients. These measures aid in assessing diastolic dysfunction in this systemic vasculitis.

Area of Science:

  • Cardiovascular Medicine
  • Rheumatology
  • Vascular Biology

Background:

  • Adamantiades-Behçet's disease (ABD) involves systemic vasculitis.
  • Potential links between vascular properties and cardiac function in ABD are not fully understood.

Purpose of the Study:

  • To investigate the relationship between aortic distensibility, arterial wave reflections, and left ventricular (LV) diastolic dysfunction in ABD patients.
  • To determine if arterial stiffness parameters can predict diastolic dysfunction in ABD.

Main Methods:

  • Applanation tonometry and echocardiography were used in 82 ABD patients and 40 controls.
  • Key parameters measured included augmentation index (AI), wave arrival time (Deltat), and aortic distensibility (AoD).
  • Left ventricular diastolic dysfunction was assessed using Doppler echocardiography criteria.

Main Results:

  • ABD patients exhibited impaired central augmentation index (CAI), Deltat, and AoD compared to controls.
  • After adjustments, AoD and CAI were significantly associated with LV diastolic dysfunction (OR 0.664, P=.04 and OR 1.073, P=.001, respectively).
  • Including CAI in models with AoD improved the prediction of LV diastolic dysfunction.

Conclusions:

  • Augmentation index provides complementary value to aortic distensibility in assessing LV diastolic dysfunction in ABD.
  • Arterial stiffness parameters are important indicators of cardiac involvement in Adamantiades-Behçet's disease.
Abstract

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