Real-time differential refractometry without interferometry at a sensitivity level of 10(-6)
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Updated: Aug 6, 2026

Diffuse Reflectance Spectroscopy: Getting the Capillary Refill Test Under One's Thumb
Published on: December 2, 2017
Michael McClimans1, Charles LaPlante, David Bonner
1Department of Physics, Miami University, Oxford, OH 45056-1866, USA.
Abstract:
We present a refractometer based on the principle of total internal reflection that can sensitively record, in real time, the refractive index of fluids over a wide range of refractive indices. The device uses a divergent laser beam and a linear diode array, and has no mechanical or optical moving parts, enabling us to achieve the measurement of a refractive index at a sensitivity level of 10(-6). Our refractometer does not rely on interferometry, thus enabling the device to be compact, portable, and inexpensive. To the best of our knowledge, this is the first time a noninterferometric device that performs real-time differential refractometry with a sensitivity of better than 10(-5) has been demonstrated in the literature. We show that our experimental results agree very well with Fresnel theory. We establish a theoretical limit on the sensitivity of this class of refractometers.
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