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Published on: May 9, 2019
[Study on spray-drier preparation technology of weitai granules using orthogonal experiments]
Cai-Hong Qu1, Li Yang, Zhi-Liang Chen
1Department of Pharmacy, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
Objective:
To screen preparation technique in order to raise the end-product and economical efficiency of spray-drier preparation technology of weitai granules.
Methods:
Newly Fluid-bed-spray-drier-granulation technique was adoped and taken extracting technique, temperature of exit and entry and the matching of accessories as inspecting factors, two levels of each factors, end-product and the water content of semi-finished weitai granules as inspecting marker, the best preparation technique of weitai granules was screened by orthogonal desing.
Results:
Among the 3 factors, the matching of accessories was most notalbe (P < 0.01), next was the temperature of exit and entry (P < 0.05). However, the extracting technique was of little importance (P > 0.05).
Conclusion:
The optimum spray-drier granulation technique of weitai granules is A3B1C3.
