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Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues
Published on: July 14, 2015
Entropic criteria for protein folding derived from recurrences: six residues patch as the basic protein word
Joseph P Zbilut1, Gek Huey Chua, Arun Krishnan
1Department of Molecular Biophysics and Physiology, Rush University Medical Center, 1653 W. Congress Parkway, Chicago, IL 60612, USA. jzbilut@rush.edu
Abstract:
Some research has suggested that patches of six constitute an important amino acid window length in proteins for conveying information. We present database evidence that supports this conjecture, as well as additional recurrence-based data that characterization and quantification of these words affect the folding/aggregation features of proteins. Other indirect evidence is presented and discussed.
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