Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Proteinuria with and without renal glomerular podocyte effacement.

Raghu Kalluri1

  • 1Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA. rkalluri@bidmc.harvard.edu

Journal of the American Society of Nephrology : JASN
|August 18, 2006
PubMed
Summary

Proteinuria, a hallmark of kidney disease, can occur without podocyte foot process effacement. Research shows glomerular basement membrane or endothelial defects can cause proteinuria independently of podocyte damage.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

CDK8 remodels the tumor microenvironment and promotes resistance to KRAS<sup>G12D</sup> inhibitors and daraxonrasib in PDAC.

The EMBO journal·2026
Same author

Advancements in extracellular vesicle research.

Extracellular vesicle·2026
Same author

Tumor-restraining fibroblasts emerge after chemotherapy specifically in responders.

Cancer cell·2026
Same author

Human extracellular vesicle blueprints.

Nature cell biology·2025
Same author

scPER: A Rigorous Computational Approach to Determine Cellular Subtypes in Tumors Aligned With Cancer Phenotypes From Total RNA Sequencing.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2025
Same author

Insights into the relevance of targeting fibroblasts to control cancer.

Cell reports. Medicine·2025

Area of Science:

  • Nephrology
  • Cell Biology
  • Pathology

Background:

  • Podocyte foot process effacement is commonly observed in kidney disease patients with proteinuria.
  • The causal relationship between proteinuria and podocyte effacement has been a long-standing question in nephrology.

Discussion:

  • Mouse models demonstrate that proteinuria can manifest without podocyte foot process effacement.
  • Defects in the glomerular basement membrane or glomerular endothelium can independently cause proteinuria.
  • This challenges the traditional view that podocyte effacement is a prerequisite for proteinuria.

Key Insights:

  • Severe glomerular basement membrane defects (e.g., COL4A3 deletion) lead to proteinuria without effacement.
  • Glomerular endothelial dysfunction (e.g., anti-VEGF treatment) causes proteinuria without effacement.

Related Experiment Videos

  • Nephrin deletion, a slit diaphragm protein, results in proteinuria independent of effacement.

    • Outlook:

    • Further investigation into the mechanisms of proteinuria in these models can reveal new therapeutic targets.
    • Human studies support the findings, suggesting broader implications for understanding kidney disease.
    • This research redefines the understanding of proteinuria pathogenesis and its relationship with podocyte injury.