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Related Experiment Videos

Childhood vasculitis and plasma exchange.

Elizabeth Wright1, Michael J Dillon, Kjell Tullus

  • 1Great Ormond Street Hospital for Children, Great Ormond Street, London WC1N 3JH, UK. liz.wright@gosh.nhs.uk

European Journal of Pediatrics
|August 18, 2006
PubMed
Summary

Therapeutic plasma exchange (TPE) shows promise in treating childhood vasculitis, particularly for organ-specific conditions. This study found TPE beneficial during acute illness phases, improving renal function and reducing inflammatory markers in pediatric patients.

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Area of Science:

  • Pediatric Nephrology
  • Rheumatology
  • Immunology

Background:

  • Retrospective review of therapeutic plasma exchange (TPE) for childhood vasculitis (1993-2003).
  • Analysis of 32 children undergoing TPE to determine short-term outcomes.

Purpose of the Study:

  • To evaluate the efficacy of TPE in treating various forms of childhood vasculitis.
  • To assess the short-term outcomes of TPE in pediatric patients with vasculitis.

Main Methods:

  • Case histories of 32 children with vasculitis treated with TPE were analyzed.
  • Vasculitis types included polyarteritis nodosa (PAN), ANCA-associated vasculitis (AAV), Henoch-Schönlein purpura (HSP), and non-classified vasculitis (NCV).

Main Results:

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  • Children with PAN showed good response, except for one with GI symptoms.
  • TPE improved renal function in ANCA-associated vasculitis (AAV) and Henoch-Schönlein purpura (HSP), with improved eGFR and creatinine clearances.
  • Inflammatory markers decreased post-TPE across all vasculitis types.

    • Conclusions:

    • Therapeutic plasma exchange (TPE) is beneficial in the acute phase of childhood vasculitis.
    • TPE is particularly effective for children with organ-specific vasculitic disease.