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Published on: July 5, 2021
Aggressive intracranial fibromatosis: case report
Oswaldo Inácio de Tella1, Luciano Ricardo França Silva, João Norberto Stavale
1Hospital São Paulo, UNIFESP, 05864-010 São Paulo SP, Brazil. detella@globo.com
Arquivos De Neuro-Psiquiatria
|August 19, 2006
Summary
Aggressive fibromatosis of the skull base is rare and challenging to treat. Complete surgical removal is often impossible, necessitating combined therapies like radiation and chemotherapy for better local control.
Area of Science:
- Neurosurgery
- Oncology
- Pathology
Background:
- Fibromatosis is a locally aggressive fibroblastic tumor.
- Intracranial fibromatosis is exceptionally rare, often affecting musculoaponeurotic structures.
Observation:
- A case of aggressive skull base fibromatosis in a 20-year-old woman is presented.
- The tumor infiltrated the sphenoid, ethmoid sinus, nasal cavity, and anterior skull base, involving the orbit.
Findings:
- Complete surgical resection was not feasible due to the tumor's extensive infiltration and proximity to critical neurovascular structures.
- The infiltrative nature of fibromatosis makes achieving clear surgical margins difficult.
Implications:
- Aggressive fibromatosis requires multimodal treatment strategies.
- Radiotherapy and chemotherapy are crucial for improving local control and preventing recurrence of intracranial fibromatosis.
