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Updated: Feb 14, 2026

Implantation and Control of Wireless, Battery-free Systems for Peripheral Nerve Interfacing
Published on: October 20, 2021
Experimental Validation of a Battery-Free RFID-Powered Implantable Neural Sensor and Stimulator
Luís Eduardo Pedigoni Bulisani1, Marco Antonio Herculano1, Carolina Chen Pauris1
1Department of Research and Postgraduate Studies, Jundiaí Medical School, Rua Francisco Telles, 250, Vila Arens, Jundiaí 13202-550, SP, Brazil.
This study validates a battery-free, RFID-powered neural interface for nerve signal acquisition and stimulation. The wireless system successfully elicited motor responses in rats, demonstrating a viable alternative to traditional implants.
Area of Science:
- Biomedical Engineering
- Neuroscience
- Implantable Devices
Background:
- Neurological injuries disrupt neural transmission, impacting quality of life.
- Current implantable stimulators have limited longevity due to internal batteries, requiring repeat surgeries.
Purpose of the Study:
- To experimentally validate a battery-free, Radio Frequency Identification (RFID)-powered neural platform.
- To achieve Technology Readiness Level-6 (TRL-6) validation for wireless neural interfaces.
Main Methods:
- Developed a prototype with an adjustable analog front-end (up to 93 dB gain) and a biphasic current-controlled stimulator.
- Conducted benchtop testing, porcine tissue assessments, and three-month in vivo trials in Wistar rats (n=3).
Main Results:
- Achieved gain accuracy within 2.2 dB and precise stimulation timing in benchtop tests.
- Maintained a stable 3.3 V wireless power link through 20 mm of biological tissue via RFID.
- Demonstrated a 100% success rate in eliciting gross motor responses wirelessly in vivo, with safe operating temperatures (<28°C).
Conclusions:
- The battery-free, RFID-powered neural interface is functionally feasible for wireless signal acquisition and stimulation.
- This architecture supports system-level validation for advanced neural interfaces.
- The technology offers a promising, less invasive alternative for neurological treatment.
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