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Trivalent arsenicals are bound to proteins during reductive methylation

Hua Naranmandura1, Noriyuki Suzuki, Kazuo T Suzuki

  • 1Graduate School of Pharmaceutical Sciences, Chiba University, Chuo, Chiba 260-8675, Japan.

Chemical Research in Toxicology
|August 22, 2006
PubMed
Summary

Inorganic arsenic methylation in rats occurs reductively, not oxidatively. Arsenic binds to proteins in trivalent forms, with pentavalent metabolites being end products, not intermediates.

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