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Progressive hypervolemia despite hypoproteinemia and massive edema formation in rats with nephrotoxic serum nephritis
C K Fujihara1, M Marcondes, R Zatz
1Nephrology Unit, University of São Paulo Medical School, Brazil.
Renal Physiology and Biochemistry
|July 1, 1990
Abstract:
Blood volume and whole kidney and single nephron function were evaluated 2 and 10 days after nephrotoxic serum nephritis (NSN) induction in Wistar rats. Progressive proteinuria, hypervolemia and edema were observed in NSN rats. Sodium retention was associated with a progressive depression of single nephron glomerular filtration rate and elevated fractional tubular reabsorption rates. Since hypervolemia rather than hypovolemia was observed in this study, edema formation must have been a consequence of intrarenal rather than extrarenal phenomena.