Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Statins and the endothelium.

Masaaki Ii1, Douglas W Losordo

  • 1Stem Cell Translational Research, RIKEN Center for Developmental Biology, 2-2 Minatojima, Minamimachi, Kobe, Japan. masa331@cdb.riken.jp

Vascular Pharmacology
|August 22, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Author Correction: Local transplantation of adipose-derived stem cells has a significant therapeutic effect in a mouse model of rheumatoid arthritis.

Scientific reports·2022
Same author

Autologous CD34+ Stem Cell Therapy Increases Coronary Flow Reserve and Reduces Angina in Patients With Coronary Microvascular Dysfunction.

Circulation. Cardiovascular interventions·2022
Same author

Hematopoietic stem-cell senescence and myocardial repair - Coronary artery disease genotype/phenotype analysis of post-MI myocardial regeneration response induced by CABG/CD133+ bone marrow hematopoietic stem cell treatment in RCT PERFECT Phase 3.

EBioMedicine·2020
Same author

CD34<sup>+</sup> cell therapy significantly reduces adverse cardiac events, health care expenditures, and mortality in patients with refractory angina.

Stem cells translational medicine·2020
Same author

Local transplantation of adipose-derived stem cells has a significant therapeutic effect in a mouse model of rheumatoid arthritis.

Scientific reports·2020
Same author

Autologous CD34+ Cell Therapy for Ischemic Tissue Repair.

Circulation journal : official journal of the Japanese Circulation Society·2019
Same journal

Interplay between Na<sup>+</sup>/K<sup>+</sup>-ATPase-dependent Src-mediated Ca<sup>2+</sup> sensitization and BK<sub>Ca</sub> channel negative feedback regulates rat mesenteric artery contraction.

Vascular pharmacology·2026
Same journal

Generation and validation of a Myh11Dre-Spp1Cre intersectional mouse model for lineage tracing of disease-associated smooth muscle cell states.

Vascular pharmacology·2026
Same journal

Prediction of peri-procedural cerebrovascular accidents in patients with severe peripheral artery disease undergoing transcatheter aortic valve replacement.

Vascular pharmacology·2026
Same journal

Vascularized tumor organoids as models for interpreting therapeutic response.

Vascular pharmacology·2026
Same journal

Spermidine ameliorates BK channel dysfunction in diabetic coronary smooth muscle cells via PKM2/STAT3/FBXO32 axis.

Vascular pharmacology·2026
Same journal

Reassessing the role of PPARgamma in vascular effects of cannabinoids: A critical appraisal.

Vascular pharmacology·2026
See all related articles

Statins offer cholesterol-independent benefits by improving endothelial function, enhancing NO production, and reducing inflammation. These pleiotropic effects highlight their therapeutic potential beyond lipid lowering.

Area of Science:

  • Cardiovascular Research
  • Endothelial Biology
  • Pharmacology

Background:

  • Statins are primarily known for lowering serum lipids.
  • The vascular endothelium is crucial in atherosclerosis and angiogenesis.
  • Endothelial dysfunction is a key factor in cardiovascular disease development.

Purpose of the Study:

  • To review the unique effects of statins on endothelial cells.
  • To highlight statins' cholesterol-independent vascular effects.
  • To explore therapeutic potential beyond lipid-lowering.

Main Methods:

  • Literature review of recent studies on statins and endothelial function.
  • Analysis of mechanisms underlying statins' effects on endothelial cells.
  • Synthesis of findings on endothelial progenitor cells and statins.

Related Experiment Videos

Main Results:

  • Statins enhance endothelial function through cholesterol-independent pathways.
  • Key mechanisms include increased nitric oxide (NO) production.
  • Statins promote re-endothelialization and inhibit vascular inflammation.

Conclusions:

  • Statins possess significant pleiotropic effects on endothelial cells.
  • These effects offer therapeutic benefits beyond lipid reduction.
  • Further research into statin's endothelial actions is warranted.