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Stem Cell Therapy for Tissue Regeneration01:21

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
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One of the common DNA damages is the chemical alteration of single bases by alkylation, oxidation, or deamination. The altered bases cause mispairing and strand breakage during replication. This type of damage causes minimal change to the DNA double helix structure and can be repaired by the base excision repair (BER) pathways. BER corrects damaged DNA sequences by removing the damaged base and restoring the original base sequence using the complementary strand as a template.
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Autologous CD34+ Cell Therapy for Ischemic Tissue Repair.

William K Sietsema1, Atsuhiko Kawamoto2, Hiroshi Takagi1

  • 1Caladrius Biosciences, Rye Brook.

Circulation Journal : Official Journal of the Japanese Circulation Society
|June 11, 2019
PubMed
Summary
This summary is machine-generated.

Autologous CD34 cell therapy shows consistent safety and clinical benefit for ischemic conditions. This review summarizes preclinical and clinical evidence from over 700 patients, supporting its therapeutic potential.

Keywords:
Cell therapyCritical limb ischemiaEndothelial progenitor cellsIschemic tissue repairRefractory angina

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Area of Science:

  • Regenerative Medicine
  • Vascular Biology
  • Hematology

Background:

  • The discovery of circulating bone marrow-derived cells in 1997 sparked debate on their role in neovascularization.
  • Despite controversy, autologous CD34 cell therapy has emerged as a promising treatment for ischemic diseases.

Purpose of the Study:

  • To review the preclinical and clinical evidence supporting autologous CD34 cell therapy.
  • To consolidate findings from over 700 patients participating in CD34 cell therapy clinical trials.

Main Methods:

  • Systematic review of preclinical studies on CD34 cell function in neovascularization.
  • Analysis of clinical trial data from patients treated with autologous CD34 cells for various ischemic conditions.

Main Results:

  • Preclinical data support the pro-angiogenic potential of CD34+ cells.
  • Clinical trials demonstrate a consistent safety profile and significant clinical benefit in patients with ischemic conditions.

Conclusions:

  • Autologous CD34 cell therapy is a safe and effective treatment for promoting neovascularization in ischemic diseases.
  • The accumulated evidence supports the clinical utility of CD34 cell therapy in managing conditions characterized by insufficient blood supply.