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A Surgical Model of Heart Failure with Preserved Ejection Fraction in Tibetan Minipigs
Published on: February 18, 2022
Prevalence, Characteristics, and Pharmacological Strategies in Patients With Heart Failure With Supranormal Ejection
Sho Suzuki1, Koichiro Kuwahara1, Akane Yamakawa2
1Shinshu University School of Medicine.
Background:
Little is known about the recently emerging entity, heart failure with supranormal ejection fraction (HFsnEF).
Methods And Results:
Subanalysis of a nationwide, prospective, observational registry that included compensated ambulatory patients with chronic HF and left ventricular ejection fraction (LVEF) >40%. Among the 4,387 patients (mean age 77 years, 43% female), 1,423 had HFsnEF. They were older, more often female, had lower natriuretic peptide levels, and exhibited smaller LV. The prescription rate of guideline-directed medical therapy was lower.
Conclusions:
HFsnEF is a common and distinct phenotype characterized by a unique profile and treatment.
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