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Antimicrobial Characterization of Advanced Materials for Bioengineering Applications
08:08

Antimicrobial Characterization of Advanced Materials for Bioengineering Applications

Published on: August 4, 2018

Impact of selective antimicrobial agents on staphylococcal adherence to biomedical devices

Charles E Edmiston1, Michael P Goheen, Gary R Seabrook

  • 1Division of Vascular Surgery, Medical College of Wisconsin, 9200 West Wisconsin Ave., Milwaukee, WI 53226, USA. edmiston@mcw.edu

American Journal of Surgery
|August 22, 2006
PubMed
Abstract

Insights

Daptomycin, rifampin, and linezolid effectively eradicated staphylococcal adherence to biomedical devices. These antibiotics showed faster and greater efficacy than vancomycin, gentamicin, or ceftriaxone in combating device-associated infections.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Biomaterials Science

Background:

  • Staphylococcal infections on biomedical devices are challenging due to biofilm formation and antimicrobial resistance.
  • Effective treatment strategies are crucial for managing these recalcitrant infections.

Purpose of the Study:

  • To evaluate the efficacy of six antimicrobial agents against biofilm-forming staphylococci on biomedical devices.
  • To compare the speed and effectiveness of different antibiotics in eradicating bacterial adherence.

Main Methods:

  • Utilized an antibiotic-lock model (ALM) and vascular graft models (Dacron, ePTFE) with five clinical staphylococcal strains.
  • Assessed bacterial adherence reduction at multiple time points (1, 2, 4, 7, 10 days) post-antibiotic exposure.

Main Results:

  • Daptomycin, rifampin, and linezolid demonstrated superior efficacy in eradicating staphylococcal adherence across tested devices.
  • These agents were significantly faster in reducing bacterial adherence compared to vancomycin, gentamicin, and ceftriaxone.
  • Ceftriaxone showed limited efficacy in eradicating staphylococcal adherence from ePTFE and Dacron grafts.

Conclusions:

  • Daptomycin, rifampin, and linezolid are highly effective against staphylococcal adherence on biomedical devices.
  • Further clinical studies are recommended to confirm the efficacy of daptomycin and linezolid for device-associated infections.

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