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Expression of p57-Kip2 in monocytes and macrophages
Thomas P J Hofer1, Marion Frankenberger, Karl J Staples
1Clinical Cooperation Group Inflammatory Lung Diseases, GSF National Research Center for Environment and Health, GSF-Institute for Inhalation Biology and Asklepios Fachkliniken Muenchen-Gauting, Robert-Koch-Allee 29, D-82131 Gauting, Germany. hofer@gsf.de
Abstract:
The p57-Kip2 gene encodes a cyclin-dependent kinase inhibitor and hence this gene has received much attention in the study of malignancy. We have analysed expression of this gene in human monocytes and macrophages. In comparison to CD14++ monocytes, p57-Kip2 expression was higher in both CD14+16+ monocytes and alveolar macrophages. p57-Kip2 expression decreased in CD14++ monocytes after stimulation with lipopolysaccharide but increased after incubation with methylprednisolone. The results indicate that p57-Kip2 may be involved in regulating the inflammatory response of monocytic cells.
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