Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mitochondrial complex I function modulates volatile anesthetic sensitivity in C. elegans.

Marni J Falk1, Ernst-Bernhard Kayser, Philip G Morgan

  • 1Department of Pediatrics, University Hospitals of Cleveland, CASE School of Medicine, Cleveland, OH 44106, USA.

Current Biology : CB
|August 22, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Targeting the Mitochondrial Phenotype in Cockayne Syndrome Patient Cells: From Bioenergetic Fragility to Pharmacologic Rescue.

bioRxiv : the preprint server for biology·2026
Same author

High-concentration MEHP triggers mtDNA depletion in undifferentiated HepaRG and C2C12 cultures and disrupts mitochondrial homeostasis in both HepaRG culture states.

Toxicological sciences : an official journal of the Society of Toxicology·2026
Same author

Targeted long-read RNA sequencing for rare disease diagnosis and variant interpretation.

Science advances·2026
Same author

A Miniaturized Enzymatic Lactate Sensor for Continuous Monitoring in Oxygen-Depleted Tissue Microenvironments.

IEEE transactions on bio-medical engineering·2026
Same author

In vitro modeling of nutritional and mitochondria-targeted therapies for osteosarcoma.

bioRxiv : the preprint server for biology·2026
Same author

Cognate amino acid therapies provide preclinical benefit in 19 <i>C. elegans</i> models of ARS2 deficiency.

bioRxiv : the preprint server for biology·2026

Volatile anesthetics

Area of Science:

  • Biochemistry
  • Genetics
  • Neuroscience

Background:

  • The precise mechanisms underlying volatile anesthetic action remain elusive despite their extensive clinical application.
  • Mitochondrial dysfunction has been proposed as a potential mechanism, but its role is not fully understood.

Purpose of the Study:

  • To investigate the role of mitochondrial function, specifically oxidative phosphorylation, in mediating the effects of volatile anesthetics.
  • To explore the link between mitochondrial complex I function and anesthetic sensitivity using a genetic model.

Main Methods:

  • Conducted genetic screens in *C. elegans* to identify mutants with altered volatile anesthetic sensitivity.
  • Analyzed mutations in genes encoding subunits of mitochondrial complexes I, II, III, and coenzyme Q.

Related Experiment Videos

  • Generated hypomorphic mutants for specific complex I subunits to further characterize their role.

    • Main Results:

    • Identified a significant correlation between complex I-dependent oxidative phosphorylation capacity and volatile anesthetic sensitivity in *C. elegans*.
    • Demonstrated that mutations affecting mitochondrial complex I directly impact anesthetic response.
    • Linked findings in a model organism to clinical observations in patients with mitochondrial myopathies.

    Conclusions:

    • Complex I-dependent oxidative phosphorylation is implicated as a primary mediator of volatile anesthetic effects.
    • Mitochondrial function is a key determinant of physiological response to volatile anesthetics.
    • This research provides a mechanistic link between mitochondrial health and anesthetic sensitivity.