Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Retinoic acid, a developmental signalling molecule.

D Summerbell1, M Maden

  • 1National Institute for Medical Research, Ridgeway, Mill Hill, London, UK.

Trends in Neurosciences
|April 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Best clinical practice guidance for treating deep carious lesions in primary teeth: an EAPD policy document.

European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry·2022
Same author

The clinical efficacy of pentoxifylline and l-glutamine on ischemia and reperfusion injury in cattle with displaced abomasum: a longitudinal study.

Polish journal of veterinary sciences·2022
Same author

Minimal intervention dentistry for managing carious lesions into dentine in primary teeth: an umbrella review.

European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry·2021
Same author

The evaluation of hemostatic dysfunction and disseminated intravascular coagulation in dairy cows with abomasal displacement.

Polish journal of veterinary sciences·2019
Same author

Mechanical reduction in intracanal Enterococcus faecalis when using three different single-file systems: an ex vivo comparative study.

International endodontic journal·2018
Same author

Reporting and Methodological Quality of Randomised Controlled Trials in Vascular and Endovascular Surgery.

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery·2015
Same journal

Building neuroscience capacity in low- and middle-income countries: Lessons from Ghana.

Trends in neurosciences·2026
Same journal

Emulating the periodic table: A unified list of CNS terms and abbreviations for humans and experimental animals.

Trends in neurosciences·2026
Same journal

From chromatin dynamics to brain disease: Polycomb-Trithorax mechanisms in neurodevelopment.

Trends in neurosciences·2026
Same journal

Striatum regulates the cortex via the basal forebrain cholinergic system: A role for substance P.

Trends in neurosciences·2026
Same journal

A large brain adds new types of neurons: Molecular and functional signatures of spindle neurons in the human neocortex.

Trends in neurosciences·2026
Same journal

Exercise as a regulator of glymphatic function.

Trends in neurosciences·2026
See all related articles

Retinoic acid (RA) is crucial for vertebrate development, influencing both cell differentiation patterns and gene expression. Recent research integrates embryology and molecular biology to understand RA

Area of Science:

  • Developmental Biology
  • Molecular Biology
  • Genetics

Background:

  • Retinoic acid (RA) is a vital signaling molecule in embryonic development.
  • Embryologists utilize RA to study spatial cell organization and pattern formation.
  • Molecular biologists investigate RA's role in regulating gene expression and cell differentiation.

Purpose of the Study:

  • To integrate embryological and molecular approaches to understand RA's developmental roles.
  • To elucidate the mechanisms by which RA controls vertebrate development.
  • To provide a comprehensive understanding of a specific vertebrate developmental system.

Main Methods:

  • Utilizing RA as a tool in embryological experiments to observe pattern modification.
  • Employing molecular biology techniques to study RA-induced gene expression changes.

Related Experiment Videos

  • Converging data from both disciplines to build a unified model.

    • Main Results:

    • RA can modify cell differentiation patterns, leading to duplication of embryonic structures.
    • RA acts as a molecular switch initiating cascades of differential gene expression.
    • The convergence of approaches has yielded significant insights into RA's function.

    Conclusions:

    • RA plays a dual role in development: patterning spatial organization and controlling gene expression.
    • The integration of embryology and molecular biology offers a powerful framework for studying development.
    • A comprehensive understanding of a vertebrate developmental system regulated by RA is now attainable.