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07:35
Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection
Published on: June 8, 2020
Fibre and colorectal cancer: a controversial question
1Hospital Son Dureta, Servi de Digestiu, Andrea Doria 55, E-07014 Palma, Mallorca, Spain. obrador@hsd.es
The British Journal of Nutrition
|August 23, 2006
Summary
Dietary fiber likely protects against colorectal cancer, despite mixed results from human trials. Animal studies and epidemiological data support fiber
Area of Science:
- Nutrition Science
- Gastroenterology
- Oncology
Background:
- The hypothesis that dietary fiber protects against colorectal cancer (CRC) emerged in the 1970s.
- Epidemiological studies generally support a beneficial role of dietary fiber in CRC prevention.
- Some intervention trials have yielded inconclusive results regarding fiber's effect on adenomatous colorectal polyps.
Purpose of the Study:
- To review the scientific literature on the controversial role of dietary fiber in colorectal cancer prevention.
- To synthesize evidence from epidemiological studies, intervention trials, and animal experiments.
- To provide recommendations regarding dietary fiber intake for CRC prevention.
Main Methods:
- Review of epidemiological studies (correlation, case-control, cohort).
- Analysis of human intervention trial data.
- Examination of animal experimental studies.
- Synthesis of existing scientific contributions on the topic.
Main Results:
- Epidemiological evidence consistently suggests a protective effect of dietary fiber against colorectal cancer.
- Intervention studies have not uniformly confirmed this preventive role concerning adenomatous polyps.
- Animal studies provide experimental support for fiber's role in CRC prevention.
Conclusions:
- Despite conflicting results from human intervention trials, the overall evidence suggests dietary fiber is important for colorectal cancer prevention.
- Continued encouragement of increased daily fiber consumption is recommended due to its probable role in CRC prevention and other health benefits.
- Further research may be warranted to elucidate the precise mechanisms and optimal intake levels.
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