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Published on: September 27, 2024
Skin rejuvenation using intense pulsed light: a randomized controlled split-face trial with blinded response
Lene Hedelund1, Eva Due, Peter Bjerring
1Department of Dermatology, University of Copenhagen and Bispebjerg Hospital, Bispebjerg Bakke 23, DK-2400 Copenhagen, Denmark. LH20@bbh.hosp.dk
Objective:
To evaluate efficacy and adverse effects of intense pulsed light rejuvenation in a homogeneous group of patients.
Design:
Randomized controlled split-face trial.
Setting:
University dermatology department.
Patients:
Thirty-two female volunteers with Fitzpatrick skin type I through III and class I or II rhytids.
Interventions:
Subjects were randomized to 3 intense pulsed light treatments at 1-month intervals or to no treatment of right or left sides of the face.
Main Outcome Measures:
Primary end points were skin texture and rhytids. Secondary end points were telangiectasia, irregular pigmentation, and adverse effects. Efficacy was evaluated by patient self-assessments and by blinded clinical and photographic evaluations up to 9 months after final treatment. Adverse effects were assessed clinically and by noninvasive skin reflectance measurements.
Results:
Skin texture was significantly improved at all clinical assessments except at the 6-month examination (P<.006). The improvements peaked at 1 month after treatment, at which time 23 (82%) of 28 patients had better appearances of treated vs untreated sides. Most patients obtained mild or moderate improvements, and 16 patients (58%) self-reported mild or moderate efficacy on skin texture. Rhytids were not significantly different on treated vs untreated sides, and 19 patients (68%) reported uncertain or no efficacy on rhytids. Significant improvements of telangiectasia (P<.001) and irregular pigmentation (P<.03) were found at all assessments. Three patients withdrew from the study because of pain related to treatment.
Conclusions:
Three intense pulsed light treatments improved skin texture, telangiectasia, and irregular pigmentation but had no efficacy on rhytids. Adverse events were minimal, but included scar in 1 patient.
