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Updated: Aug 5, 2026

Oral Combinational Antiretroviral Treatment in HIV-1 Infected Humanized Mice
Published on: October 6, 2022
Human immunodeficiency virus-type 1 specific cellular immunity in chronic infected patients on prolonged highly
Reikei Matsuda1, Ann-Charlotte Boström, Malin Fredriksson
1Swedish Institute for Infectious Disease Control, Microbiology and Tumor Biology Center, Karolinska Institute, Novelsvägen, Solna, Sweden. reikeim@hotmail.com
Abstract:
We have followed 15 HIV-1 chronically infected patients during prolonged highly active antiretroviral treatment (HAART) and subsequent long term structured treatment interruption (STI). We analyzed Nef, Tat, and p24 specific cellular immunity using IFN-gamma enzyme-linked immunospot assays and T cell proliferation assays. Eight HAART patients showed IFN-gamma responses to at least one antigen, but no positive responses were seen during STI. We observed retained or increased p24 specific IFN-gamma responses in most patients during HAART with viral suppression. These results showed persisting HIV-1 specific cellular immunity during HAART; however, in prolonged STI with viral rebound this immunity declined.
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