[Pentavalent vaccine and vaccination coverage in children aged less than one in Colombia 2000-2003]

Jaid C Rojas-Sotelo1, Franklyn E Prieto-Alvarado

  • 1Ministerio de la Protección Social. jaidrojas@yahoo.com

Insights

The pentavalent vaccine significantly improved childhood immunisation coverage, increasing the number of municipalities reaching 80% coverage. Continued financing is crucial for sustaining vaccination programs and developing new combination vaccines.

Area of Science:

  • Public Health
  • Vaccinology
  • Epidemiology

Background:

  • Childhood immunisation is critical for disease prevention.
  • Assessing the impact of new vaccine introductions on coverage rates is essential for public health policy.

Purpose of the Study:

  • To determine the impact of introducing the pentavalent vaccine on third-dose immunisation coverage in children under one year.
  • To analyze changes in coverage by geographic cluster.

Main Methods:

  • An ecological study design was employed.
  • Data were analyzed using administrative units (department, province, municipality, capital city).
  • Third-dose coverage, desertion index, and the number of municipalities achieving >80% coverage were compared pre- and post-vaccine introduction.

Main Results:

  • Overall immunisation coverage increased from 23% to 26%, with notable gains for Haemophilus influenzae type b (Hib3).
  • The desertion index decreased significantly from 9.3-31.7% to 0.3%.
  • The number of municipalities with >80% coverage more than doubled, from 265 to 627.

Conclusions:

  • The pentavalent vaccine introduction positively impacted immunisation coverage rates.
  • Sustained financing is recommended to ensure vaccine availability and support research into new combination vaccines.
Abstract

Related Concept Videos

Vaccinations01:51

Vaccinations

Overview
Smallpox01:24

Smallpox

Smallpox is a severe contagious disease caused by the Variola major virus, a double-stranded DNA member of the Poxviridae family.Variola major transmission occurs primarily via inhalation of virus-laden droplets or direct contact with infectious scabs. The incubation period averages approximately seven days, although it may range from 7 to 17 days depending on the inoculum and host factors.Clinically, the prodromal phase is marked by an abrupt onset of high fever, malaise, headache, and myalgia.
Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
Prevalence and Incidence01:08

Prevalence and Incidence

In statistical epidemiology and health sciences, two essential metrics—prevalence and incidence—are fundamental for understanding disease dynamics within a population. These measures enable public health officials, epidemiologists, and researchers to assess the burden of diseases, allocate resources effectively, and design impactful public health policies and interventions.
Prevalence indicates the proportion of individuals in a population who have a specific disease or health condition at a...
Vaccines01:21

Vaccines

Vaccines are among the most effective tools in preventive medicine, designed to prepare the immune system to recognize and combat infectious agents. By introducing antigens—substances that the immune system identifies as foreign—vaccines stimulate an adaptive immune response that leads to immunological memory. This immunological memory enables the body to mount a faster and more effective response upon future exposures to the actual pathogen.Vaccines can be categorized based on the type of...
Poliomyelitis01:17

Poliomyelitis

Poliomyelitis is caused by poliovirus, a small, non-enveloped, positive-sense RNA virus of the Picornaviridae family and Enterovirus genus. Transmission occurs primarily via the fecal-oral route, often through ingestion of contaminated water or food. The virus initially replicates in the oropharynx and intestinal mucosa, particularly in lymphoid tissues such as the tonsils, Peyer’s patches, and regional lymph nodes. Primary viremia follows, allowing dissemination throughout the body.In most...