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Efficient Synthesis of All-Carbon Quaternary Centers via the Conjugate Addition of Functionalized Monoorganozinc Bromides
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Remarkably stable chiral zirconium complexes for asymmetric Mannich-type reactions

Kowichiro Saruhashi1, Shu Kobayashi

  • 1Graduate School of Pharmaceutical Sciences, The University of Tokyo, The HFRE Division, ERATO, Japan Science Technology Agency (JST), Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

Journal of the American Chemical Society
|August 24, 2006
PubMed
Summary

New chiral zirconium catalysts enable highly selective asymmetric Mannich-type reactions. These isolable, reusable catalysts offer high yields and stereoselectivities, simplifying complex chemical synthesis.

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