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DNA Microarrays

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...

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ampliPHOX Colorimetric Detection on a DNA Microarray for Influenza

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The emergence and diffusion of DNA microarray technology.

Tim Lenoir¹, Eric Giannella

¹Jenkins Collaboratory for New Technologies in Society, Duke University, John Hope Franklin Center, 2204 Erwin Road, Durham, North Carolina 27708-0402, USA. lenoir@duke.edu

Journal of Biomedical Discovery and Collaboration

|August 24, 2006

Summary

Innovation thrives in open, networked economies. This study shows how industry advancements, supported by federal funding, significantly reshape academic research agendas, demonstrating a two-way flow of knowledge and invention.

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ampliPHOX Colorimetric Detection on a DNA Microarray for Influenza

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Published on: June 9, 2011

DNA Microarrays: Sample Quality Control, Array Hybridization and Scanning

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Published on: March 15, 2011

High-Density DNA and RNA microarrays - Photolithographic Synthesis, Hybridization and Preparation of Large Nucleic Acid Libraries

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Published on: August 12, 2019

Area of Science:

Economics of Science and Technology
Innovation Studies
Biotechnology

Background:

The network model of innovation posits porous boundaries and bi-directional knowledge flow between industry and academia.
While industry adoption of university inventions is well-studied, industry's influence on academic research remains underexplored.
Federal funding plays a crucial role in this dynamic, particularly in emerging fields like microarrays.

Purpose of the Study:

To investigate the impact of industry-driven innovation on academic research agendas.
To analyze the role of federal funding in fostering bi-directional knowledge exchange in the microarray field.
To provide a detailed case study of microarray technology development and diffusion.

Main Methods:

Qualitative analysis of the development and diffusion of microarray technologies.
Tracing the origins and evolution of microarray platforms from both industry and academic sources.
Examining the influence of federal funding on research and development in the microarray ecosystem.

Main Results:

Microarray technology emerged from a network drawing on diverse knowledge resources from startups, large firms, and universities.
Federal funding was instrumental in the early development of commercial microarray technologies.
Federally funded microarray adoption fundamentally transformed research agendas in multiple academic fields.

Conclusions:

Open, networked systems are essential for innovation, as demonstrated by the microarray case.
Knowledge spillovers in innovation are bi-directional, with industry advancements significantly influencing academic research.
Federal funding acts as a catalyst for both industrial development and the reshaping of academic research priorities.