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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Pulmonary involvement in ankylosing spondylitis.

Francisco P Quismorio¹

¹Division of Rheumatology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, 90033, USA. quismori@usc.edu

Current Opinion in Pulmonary Medicine

|August 24, 2006

Summary

Pulmonary abnormalities are common in ankylosing spondylitis (AS) patients, often detected by high-resolution computed tomography (HRCT) even without symptoms. The clinical impact of these HRCT findings in AS requires further investigation.

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Du-Moxibustion in a Mouse Model of Ankylosing Spondylitis

Du-Moxibustion in a Mouse Model of Ankylosing Spondylitis

Published on: October 27, 2023

Area of Science:

Rheumatology and Pulmonology
Medical Imaging

Background:

Ankylosing spondylitis (AS) management has advanced with anti-tumor necrosis factor-alpha (anti-TNFα) agents.
Pulmonary manifestations in AS patients warrant a review in light of these therapeutic developments.

Purpose of the Study:

To review recent observations on pulmonary manifestations in ankylosing spondylitis.
To contextualize these findings within current AS treatment paradigms.

Main Methods:

Review of recent literature on pulmonary manifestations in ankylosing spondylitis.
Analysis of findings from high-resolution computed tomography (HRCT) scans.
Consideration of correlations with pulmonary function tests and disease severity.

Main Results:

High-resolution computed tomography (HRCT) abnormalities are prevalent (50-85%) in ankylosing spondylitis (AS), including early disease stages.
Observed HRCT changes include apical fibrosis, interstitial lung disease, emphysema, bronchiectasis, and pleural thickening, generally mild.
No significant correlation found between HRCT abnormalities and pulmonary function or AS disease severity; spontaneous pneumothorax is a rare complication in fibrobullous disease.

Conclusions:

The clinical significance of HRCT abnormalities in ankylosing spondylitis (AS) remains undetermined.
Current studies are limited by cross-sectional design and lack of matched controls.
Further research, including prospective studies and correlation with invasive lung assessments, is needed to understand long-term evolution and the impact of anti-TNFα therapy.