Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

NG-hydroxyguanidines from primary amines.

Nathaniel I Martin1, Joshua J Woodward, Michael A Marletta

  • 1Department of Chemistry, University of California-Berkeley, 204 Lewis Hall, Berkeley, CA 94720, USA. nimartin@berkeley.edu

Organic Letters
|August 25, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Copper-Dependent Polysaccharide Monooxygenases: Mechanism and Function.

Chemical reviews·2026
Same author

β-lactamase-mediated hydrolysis of cloxacillin increases tolerance in Escherichia coli.

npj antimicrobials and resistance·2026
Same author

Optimisation of a Novel Class of DNA Gyrase Inhibitors to Improve Antibacterial Activity.

ChemMedChem·2026
Same author

Molecular action of NZ2114, a superior plectasin derivative.

npj antimicrobials and resistance·2026
Same author

Structure-Activity Studies on the Antitubercular Natural Product Evybactin.

ACS medicinal chemistry letters·2026
Same author

Paenitracins, a novel family of bacitracin-type nonribosomal peptide antibiotics produced by plant-associated <i>Paenibacillus</i> species.

mSystems·2026

Researchers developed a straightforward method to synthesize N(G)-hydroxyguanidines from primary amines. This one-pot procedure yields protected compounds, including N(G)-hydroxy-L-arginine, a key nitric oxide synthase intermediate.

Area of Science:

  • Organic Chemistry
  • Biochemistry

Background:

  • N(G)-hydroxyguanidines are important molecules in biological pathways.
  • Existing synthesis methods may be complex or require specific reagents.

Purpose of the Study:

  • To develop a concise and general method for preparing N(G)-hydroxyguanidines.
  • To provide a high-yielding route to N(G)-hydroxy-L-arginine.

Main Methods:

  • A one-pot procedure converting primary amines to protected N(G)-hydroxyguanidines.
  • Deprotection under nonreducing conditions.

Main Results:

  • Successful synthesis of various protected N(G)-hydroxyguanidines.
  • High-yielding preparation of N(G)-hydroxy-L-arginine achieved.

Related Experiment Videos

Conclusions:

  • The reported method offers a general and efficient approach for N(G)-hydroxyguanidine synthesis.
  • This method facilitates the preparation of key intermediates like N(G)-hydroxy-L-arginine for biochemical studies.