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Updated: Jul 20, 2026
12:26
Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay
Published on: May 3, 2018
The role of cyclin-dependent kinases in T-cell development, proliferation, and function
Emily A Rowell1, Andrew D Wells
1Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, 19104.
Critical Reviews in Immunology
|August 25, 2006
Summary
T lymphocytes control cell cycle progression using cyclins and cyclin-dependent kinases. Their coordinated activities impact T-cell development, function, memory, and tolerance.
Area of Science:
- Immunology
- Molecular Biology
- Cell Biology
Background:
- T lymphocyte cell cycle progression is crucial for immune responses.
- Regulation involves cyclins, cyclin-dependent kinases (CDKs), and CDK inhibitors.
- Extracellular signals integrate through T-cell receptors (TCRs) to modulate cell cycle.
Purpose of the Study:
- To review how T lymphocytes integrate signals for cell cycle progression.
- To discuss the role of cell cycle regulators in T-cell function.
- To explore the impact on T-cell development, homeostasis, memory, and tolerance.
Main Methods:
- Literature review of molecular mechanisms controlling T-cell cycle.
- Analysis of signaling pathways integrating TCR, costimulatory, and cytokine receptor inputs.
- Examination of the roles of cyclins, CDKs, and CDK inhibitors in T-cell biology.
Main Results:
- Ordered expression/degradation of cyclins and CDKs drives T-cell cycle.
- CDK inhibitors act as crucial negative regulators.
- Signal integration dictates cell cycle commitment and progression.
Conclusions:
- Coordinated protein activities are essential for T-cell cycle control.
- Cell cycle regulation underpins diverse T-cell functions.
- Understanding these mechanisms is key for immune memory and tolerance induction.
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