Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Microvascular changes in the diabetic foot.

Jordan C Schramm1, Thanh Dinh, Aristidis Veves

  • 1Microcirculation, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.

The International Journal of Lower Extremity Wounds
|August 25, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

MIAAIM: Multi-omics image integration with dimensional reduction for tissue state mapping.

PLoS computational biology·2026
Same author

Intelligent In situ Printing of Multimaterial Bioinks for First-Aid Wound Care Guided by Eye-In-Hand Robot Technology.

Advanced materials technologies·2025
Same author

Microcirculation of the Diabetic Foot.

Clinics in podiatric medicine and surgery·2025
Same author

Integrated machine learning analysis of proteomic and transcriptomic data identifies healing associated targets in diabetic wound repair.

Scientific reports·2025
Same author

Management of Diabetic Wounds: Expert Panel Consensus Statement.

Advances in wound care·2025
Same author

Effect of continuous positive airway pressure on ventricular remodeling of patients with combined diabetes mellitus and obstructive sleep apnea: a cross-sectional study and follow-on randomized clinical trial.

International journal of cardiology·2025
Same journal

Pacinian Corpuscle Distribution, Density, and Morphology of the Adult Human Foot in Health and Diabetes: A Scoping Review.

The international journal of lower extremity wounds·2026
Same journal

Genetic Evidence for Adiposity-Related Susceptibility and Heel BMD-Proxied Skeletal Resilience in Charcot Foot: A Two-Sample Mendelian Randomization Study.

The international journal of lower extremity wounds·2026
Same journal

Metabolic Intensification in Limb Salvage: A Doubly Robust Dual-Center Study Establishing 37.9 g/L as the Physiological Requirement for Diabetic Foot Ulcer Regeneration.

The international journal of lower extremity wounds·2026
Same journal

Efficacy and Safety of Kangfuxin Liquid Adjuvant Therapy Versus Standard Dressing in Treating Stage II-III Pressure Ulcers: A Meta-Analysis of Randomized Controlled Trials.

The international journal of lower extremity wounds·2026
Same journal

Revealing the Association Between Dietary Quality index and Diabetic Foot Ulcer: A Case-Control Study.

The international journal of lower extremity wounds·2026
Same journal

SGLT-2 Inhibitors and Lower-limb Amputations in Diabetes: A Misunderstood Relationship? Insights from a Retrospective Study.

The international journal of lower extremity wounds·2026
See all related articles

Diabetic microcirculation impairment hinders lower extremity wound healing. Functional changes in blood vessels and nerve reflexes reduce vasodilation, increasing risks of foot infections and ulcers.

Area of Science:

  • Vascular biology
  • Diabetic complications
  • Microcirculation research

Background:

  • Diabetic patients often experience microcirculatory dysfunction, leading to lower extremity complications like infections and ulcerations.
  • These microcirculatory issues are primarily functional, affecting the blood vessels' ability to dilate when injured.
  • Dysfunction in vascular endothelial and smooth muscle cells contributes to reduced vasodilation in diabetics.

Purpose of the Study:

  • To investigate the role of microcirculatory impairment in diabetic lower extremity complications.
  • To understand the functional changes in microvasculature contributing to impaired wound healing.
  • To explore the contribution of endothelial and smooth muscle cell dysfunction to reduced vasodilation.

Main Methods:

Related Experiment Videos

  • Analysis of microcirculatory function in diabetic patients.
  • Assessment of vascular endothelial and smooth muscle cell responses.
  • Evaluation of nerve-axon reflex mechanisms in microvascular vasodilation.

    • Main Results:

    • Microcirculatory changes in diabetics are mainly functional, impairing vasodilation.
    • Both endothelial and smooth muscle cell dysfunction reduce blood vessel dilation.
    • Impaired nerve-axon reflex vasodilation is observed in the diabetic population.

    Conclusions:

    • Impaired vasodilation and nerve-axon reflex dysfunction are key factors in poor diabetic wound healing.
    • Further research is needed to identify the exact causes of endothelial and smooth muscle dysfunction.
    • Understanding these mechanisms could lead to new therapeutic strategies for diabetic foot complications.