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Intelligent In situ Printing of Multimaterial Bioinks for First-Aid Wound Care Guided by Eye-In-Hand Robot

Seol-Ha Jeong1, Jihyun Kim1,2, Brendan Craig Thibault1,3

  • 1Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02139, USA.

Advanced Materials Technologies
|December 23, 2025
PubMed
Summary

A new robotic system, INSIGHT (INtelligent in situ printing Guided by Eye-in-Hand robot Technology), enables precise, real-time wound treatment through advanced computer vision and 3D printing. This technology facilitates customized bandages and scaffolds for diverse wound types, improving patient care.

Keywords:
in situ bioprintingrobot printingspray printingvisual guidancewound healing

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Area of Science:

  • Biomedical Engineering
  • Robotics
  • Computer Vision

Background:

  • Advanced wound care requires precise and adaptable treatment methods.
  • Current technologies may lack the flexibility for real-time, customized wound management.

Purpose of the Study:

  • To introduce INSIGHT, a computer vision-enabled robotic system for intelligent in situ printing.
  • To demonstrate the system's capability for real-time wound assessment and treatment fabrication.

Main Methods:

  • Utilized a depth camera and a 6-DOF robot arm for real-time adjustments and arbitrary area identification.
  • Implemented dynamic image recognition based on color and contour differences for volumetric printing.
  • Integrated an optimized pneumatic valve for printing diverse inks and dual printing modes (extrusion and spray).

Main Results:

  • Achieved continuous targeting of multiple wounds at different locations.
  • Fabricated scaffolds and bandages with capacity to treat various wound types.
  • Demonstrated reduced printing time for large-scale wounds on an ex vivo porcine model.
  • Successfully treated diabetic wounds using a microgel-based ink facilitating cell infiltration.

Conclusions:

  • INSIGHT system offers adaptable, customized care for rapid emergency treatment of trauma patients.
  • The technology shows potential for revolutionizing wound management through intelligent, in situ fabrication.