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Related Experiment Video

Updated: Jun 2, 2026

Simultaneous Brightfield, Fluorescence, and Optical Coherence Tomographic Imaging of Contracting Cardiac Trabeculae Ex Vivo
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Tailored-Reflectivity Microstructures for Measuring Signal Sensitivity of Optical Coherence Tomography Medical

Declan M Fitzgerald1, Greta Babakhanova2, Christopher M Stafford3

  • 1Center for Devices and Radiological Health, Food and Drug Administration Silver Spring, MD 20993, USA; Department of Mechanical Engineering, University of Maryland, College Park, MD 20742, USA; Department of Mechanical Engineering, University of California, Berkeley, CA 94720, USA.

Advanced Materials Technologies
|June 1, 2026
PubMed
Summary
This summary is machine-generated.

A new microstructure phantom directly measures Optical Coherence Tomography (OCT) sensitivity, improving diagnostic accuracy. This tool enhances the reliability of OCT imaging for ophthalmology and other medical applications.

Keywords:
3D Printingadditive manufacturingdirect laser writingophthalmic imagingoptical coherence tomographysignal sensitivity

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Last Updated: Jun 2, 2026

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In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography

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Area of Science:

  • Biomedical Imaging
  • Ophthalmology
  • Optical Engineering

Background:

  • Optical Coherence Tomography (OCT) is crucial in ophthalmology for high-resolution imaging of ocular structures, especially the retina.
  • Current methods for evaluating OCT system sensitivity are indirect and extrapolate from high-signal data.
  • There is a need for direct sensitivity evaluation tools to match OCT's technological advancements.

Purpose of the Study:

  • To develop a novel phantom for directly evaluating OCT system sensitivity.
  • To introduce advanced fabrication techniques for creating biomimetic retinal phantoms.
  • To establish a regulatory science tool for consistent OCT performance reporting.

Main Methods:

  • Fabrication of a novel microstructure array phantom using two-photon direct laser writing (DLW).
  • Application of thermally activated selective topographic equilibrium (TASTE) for creating optically smooth microstructures.
  • Direct quantification of OCT sensitivity threshold using the fabricated phantom.

Main Results:

  • The novel phantom effectively and directly quantifies OCT sensitivity threshold.
  • The fabrication methods demonstrate potential for creating complex, biomimetic retinal phantoms.
  • The phantom serves as a proof-of-concept for a disseminable regulatory science tool.

Conclusions:

  • The developed microstructure phantom enables direct OCT sensitivity evaluation, surpassing current indirect methods.
  • Advanced fabrication techniques pave the way for next-generation, geometrically complex retinal phantoms.
  • This tool will enhance consistency and reliability in OCT performance reporting across various applications.