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Updated: Jul 20, 2026
10:04
Establishment of Proliferative Tetraploid Cells from Nontransformed Human Fibroblasts
Published on: January 8, 2017
DNA ploidy in proliferative verrucous leukoplakia
P Klanrit1, M Sperandio, A L Brown
1Department of Oral Pathology, King's College London Dental Institute, Floor 28 Guy's Tower, Guy's Hospital, London SE1 9RT, UK.
Oral Oncology
|August 26, 2006
Summary
Proliferative verrucous leukoplakia (PVL) can progress to squamous cell carcinoma. DNA ploidy analysis of lesional epithelium may predict malignant transformation and its site in oral leukoplakia.
Area of Science:
- Oral pathology
- Oncology
- Genetics
Background:
- Proliferative verrucous leukoplakia (PVL) is a distinct oral leukoplakia subtype.
- PVL lesions are multifocal, verrucous, and have a high risk of progressing to squamous cell carcinoma.
Purpose of the Study:
- To detail the clinical and histopathological characteristics of six PVL cases.
- To assess DNA ploidy anomalies in PVL epithelium for predicting malignant transformation.
Main Methods:
- Review of clinical and pathological data from six PVL patients.
- Image-based DNA ploidy analysis of biopsy specimens.
Main Results:
- The study included 5 females and 1 male, average age 66; only one patient used tobacco and alcohol.
- Alveolar ridge/gingiva was the most common site (6/6).
- DNA ploidy anomalies predicted malignant transformation in 4/5 cases and indicated the transformation site in 3/4 carcinomas.
Conclusions:
- DNA ploidy analysis, alongside histopathology, shows promise in predicting malignant transformation and its location in proliferative verrucous leukoplakia.
- PVL has a high rate of malignant transformation, often occurring at sites with identified ploidy anomalies.
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