Related Experiment Video
Updated: Jul 20, 2026
06:38
Screening and Isolation of C-Glycoside-Cleaving Intestinal Bacteria
Published on: February 28, 2025
Flavone c-glycosides from Trollius ledebouri reichb
1Laboratory of Phytochemistry, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China.
Journal of Asian Natural Products Research
|August 26, 2006
Summary
A new acylated C-glycosylflavone was discovered in Trollius ledebouri, alongside two known compounds. These C-glycosylflavones were evaluated for their anti-inflammatory effects in a mouse model.
Area of Science:
- Phytochemistry
- Pharmacology
Background:
- Trollius ledebouri Reichb is a plant source of bioactive compounds.
- C-glycosylflavones are a class of natural products with potential biological activities.
Purpose of the Study:
- To isolate and characterize a new acylated C-glycosylflavone from Trollius ledebouri.
- To evaluate the anti-inflammatory potential of isolated C-glycosylflavones.
Main Methods:
- Isolation of compounds using chromatographic techniques.
- Structure elucidation via High-Resolution Mass Spectrometry (HRMS), Infrared (IR) spectroscopy, and Nuclear Magnetic Resonance (NMR) (1H, 13C, COSY, HMQC, HMBC).
- In vivo anti-inflammatory activity testing using TPA-induced mice ear edema.
Main Results:
- A novel acylated C-glycosylflavone (compound 1) was successfully isolated and identified.
- Two known C-glycosylflavones (compounds 2 and 3) were also isolated.
- Compounds 1-3 demonstrated anti-inflammatory activity in the TPA-induced mice ear edema model.
Conclusions:
- Trollius ledebouri yielded a new acylated C-glycosylflavone.
- The isolated C-glycosylflavones possess anti-inflammatory properties, warranting further investigation.
Related Concept Videos
01:15Antifungal Agents
Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to cholesterol contributes to...
01:29Bacterial Flora of the Large Intestine
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.