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The Use of Reverse Phase Protein Arrays (RPPA) to Explore Protein Expression Variation within Individual Renal Cell Cancers
Published on: January 22, 2013
Technology Insight: renal proteomics--at the crossroads between promise and problems
Edmond O'Riordan1, Steven S Gross, Michael S Goligorsky
1Department of Medicine, Renal Institute and Division of Nephrology, New York Medical College, Valhalla, NY 10595, USA. edmond_oriordan@nymc.edu
Nature Clinical Practice. Nephrology
|August 26, 2006
Summary
Emerging proteomic technologies show promise for diagnosing renal disease by analyzing urine and kidney proteins. Further research and standardization are needed to overcome current challenges in this field.
Area of Science:
- Biochemistry
- Nephrology
- Genomics
Background:
- Human genome knowledge advances proteomic research.
- Proteomics is an emerging field with potential in disease diagnosis.
Purpose of the Study:
- To review the application of proteomic technologies for renal disease diagnosis.
- To discuss the potential, efficacy, and challenges of proteomic approaches in nephrology.
Main Methods:
- Review of recent proteomic technologies.
- Analysis of studies using urinary proteome for renal disease diagnosis.
- Presentation of renal proteome data.
Main Results:
- Proteomic technologies offer potential diagnostic tools for renal diseases.
- Current challenges include limited knowledge of the urine proteome and need for standardization.
- Bioinformatics plays a crucial role in data analysis.
Conclusions:
- Proteomics holds significant promise for the diagnosis of renal diseases.
- Standardization of sample handling and reporting is essential for clinical application.
- Further research is required to fully realize the diagnostic potential of proteomics in nephrology.
