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FGF23: its role in renal bone disease
Masafumi Fukagawa1, Junichiro James Kazama
1Division of Nephrology and Dialysis Center, Kobe University School of Medicine, Kobe 650-0017, Japan. fukagawa@med.kobe-u.ac.jp
Pediatric Nephrology (Berlin, Germany)
|August 26, 2006
Summary
Fibroblast growth factor 23 (FGF23) is crucial for phosphate homeostasis. In chronic kidney disease, high FGF23 levels indicate secondary hyperparathyroidism and predict treatment response.
Area of Science:
- Endocrinology
- Nephrology
- Mineral Metabolism
Background:
- Fibroblast growth factor 23 (FGF23) is a bone-derived hormone regulating phosphate and vitamin D metabolism.
- In chronic kidney disease (CKD), FGF23 plays a role in mineral and bone disorder (CKD-MBD).
Purpose of the Study:
- To review the role of FGF23 in CKD-MBD.
- To highlight FGF23's utility as a biomarker in dialysis patients.
Main Methods:
- Review of current literature on FGF23 in CKD.
- Analysis of FGF23's role in phosphate homeostasis and vitamin D suppression.
Main Results:
- FGF23 is essential for phosphate excretion and suppresses 1,25-dihydroxyvitamin D production.
- In advanced CKD, FGF23 contributes to hyperphosphatemia and secondary hyperparathyroidism.
- Elevated FGF23 predicts refractory hyperparathyroidism and vitamin D therapy response in dialysis patients.
Conclusions:
- FGF23 is a key regulator of mineral balance in CKD.
- Serum FGF23 levels are valuable predictors in dialysis patients.
- Further research is needed to fully understand FGF23's functions in CKD-MBD.
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