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Assessment of Vascular Function in Patients With Chronic Kidney Disease
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Published on: June 16, 2014

Resting Heart Rate and Incident CKD Among Individuals With CKD Risk Factors.

Hirotaka Saito1, Kenichi Tanaka1,2, Hiroshi Kimura1,2

  • 1Department of Nephrology and Hypertension, Fukushima Medical University, Fukushima, Japan.

Nephrology (Carlton, Vic.)
|May 21, 2026
PubMed
Summary

A higher resting heart rate (RHR) is linked to increased chronic kidney disease (CKD) risk in individuals with CKD risk factors. This study highlights RHR as a potential indicator for CKD development.

Keywords:
chronic kidney diseasecohort studyheart rate

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Area of Science:

  • Nephrology
  • Cardiology
  • Epidemiology

Background:

  • Elevated resting heart rate (RHR) is a known risk factor for mortality and cardiovascular events.
  • The association between RHR and the development of chronic kidney disease (CKD) in individuals with existing CKD risk factors is not well-established.

Purpose of the Study:

  • To investigate the association between baseline RHR and the incidence of CKD.
  • To evaluate RHR as a potential predictor for new-onset CKD in a cohort with established CKD risk factors.

Main Methods:

  • Analysis of 1210 participants from the Fukushima Cohort Study with CKD risk factors but no baseline CKD or proteinuria.
  • Participants were categorized into RHR groups: <70 bpm (reference), 70-79 bpm, and ≥80 bpm.
  • Cox proportional hazards models were used to assess associations, adjusting for relevant covariates.

Main Results:

  • During a mean follow-up of 4.3 years, 353 participants developed CKD.
  • A RHR ≥80 bpm was associated with a 1.35-fold increased risk of incident CKD compared to the reference group (<70 bpm).
  • The association was more pronounced in participants with diabetes.

Conclusions:

  • Higher resting heart rate is associated with an increased risk of incident chronic kidney disease.
  • RHR may serve as a valuable clinical marker for predicting CKD development in at-risk populations.